NUDT15 Polyclonal Antibody

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£195.30

Was £217.00

SKU:: E-AB-64940
Additional Names:: MTH2,NUDT15,NUDT15D
Application:: WB
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human NUDT15 (NP_060753.1).
Uniprot:: Q9NV35
Synonyms:: 8-oxo-dGTPase NUDT15;MTH2;mutT homolog 2;Nucleoside diphosphate-linked moiety X motif 15;nucleoside diphosphate-linked to another moiety X hydrolase 15;nucleotide triphosphate diphosphatase NUDT15;nudix (nucleoside diphosphate linked moiety X)-type motif 15;NUDT15D;probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15;probable 8-oxo-dGTP diphosphatase NUDT15
Extra Details:: This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.