E-AB-64807
CAMLG Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-64807
- Additional Names:
- CAML,CAMLG,GET2
- Application:
- IHC, WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human CAMLG (NP_001736.1).
- Uniprot:
- P49069
- Synonyms:
- calcium signal-modulating cyclophilin ligand;calcium-modulating cyclophilin ligand;CAML;cyclophilin B-binding protein;GET2;guided entry of tail-anchored proteins factor CAMLG
- Extra Details:
- The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
- Shipping Conditions:
- Blue Ice