ALAS1 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-64653
Additional Names:: ALAS,ALAS-H,ALAS1,ALAS3,ALASH,MIG4
Application:: IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human ALAS1 (NP_954635.1).
Uniprot:: P13196
Synonyms:: 5-aminolevulinate synthase, nonspecific, mitochondrial;5-aminolevulinic acid synthase 1;ALAS;ALAS-H;ALAS3;ALASH;aminolevulinate, delta-, synthase 1;delta-ALA synthase 1;delta-aminolevulinate synthase 1;MIG4;migration-inducing protein 4
Extra Details:: This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme, a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms.