E-AB-64526
XIAP Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-64526
- Additional Names:
- API3,BIRC4,IAP-3,ILP1,MIHA,XIAP,XLP2,hIAP-3,hIAP3
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human XIAP (NP_001158.2).
- Uniprot:
- P98170
- Synonyms:
- API3;baculoviral IAP repeat-containing protein 4;BIRC4;E3 ubiquitin-protein ligase XIAP;hIAP-3;hIAP3;IAP-3;IAP-like protein;IAP-like protein 1;ILP1;inhibitor of apoptosis protein 3;MIHA;RING-type E3 ubiquitin transferase XIAP;X-linked IAP;X-linked inhibitor of apoptosis protein;X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase;XLP2
- Extra Details:
- This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
- Shipping Conditions:
- Blue Ice