PIWIL4 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-64500
Additional Names:: HIWI,MIWI,PIWIL,PIWIL4,HIWI2,MIWI2,PIWI
Application:: WB
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human PIWIL4 (NP_689644.2).
Uniprot:: Q7Z3Z4
Synonyms:: HIWI2;MIWI2;piwi-like 4;piwi-like protein 4;testis tissue sperm-binding protein Li 85P
Extra Details:: PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association.