SPTA1 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-63689
Additional Names:: EL2,HPP,HS3,SPH3,SPTA,SPTA1
Application:: IHC, IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human SPTA1 (NP_003117.2).
Uniprot:: P02549
Synonyms:: alpha-I spectrin;EL2;elliptocytosis 2;erythroid alpha-spectrin;HPP;HS3;spectrin alpha chain, erythrocyte;spectrin alpha chain, erythrocytic 1;SPH3;SPTA
Extra Details:: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.