PCBP1 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-63397
Additional Names:: HEL-S-85,HNRPE1,HNRPX,PCBP1,hnRNP-E1,hnRNP-X
Application:: IHC, WB, IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: A synthetic peptide of human PCBP1 (NP_006187.2).
Uniprot:: Q15365
Synonyms:: alpha-CP1;epididymis secretory protein Li 85;HEL-S-85;heterogeneous nuclear ribonucleoprotein E1;heterogenous nuclear ribonucleoprotein E1;heterogenous nuclear ribonucleoprotein X;hnRNP-E1;hnRNP-X;HNRPE1;HNRPX;nucleic acid-binding protein SUB2.3;poly(rC)-binding protein 1
Extra Details:: This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Shipping Conditions:: Blue Ice