E-AB-63008
MDC1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-63008
- Additional Names:
- MDC1,NFBD1
- Application:
- IHC, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human MDC1 (NP_055456.2).
- Uniprot:
- Q14676
- Synonyms:
- homologue to Drosophila photoreceptor protein calphotin;mediator of DNA damage checkpoint protein 1;NFBD1;nuclear factor with BRCT domains 1
- Extra Details:
- The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
- Shipping Conditions:
- Blue Ice