E-AB-62982
DPM1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-62982
- Additional Names:
- CDGIE,DPM1,MPDS
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human DPM1 (NP_003850.1).
- Uniprot:
- O60762
- Synonyms:
- CDGIE;dolichol monophosphate mannose synthase;dolichol-phosphate mannose synthase subunit 1;dolichol-phosphate mannosyltransferase subunit 1;dolichyl-phosphate beta-D-mannosyltransferase subunit 1;dolichyl-phosphate mannosyltransferase polypeptide 1 catalytic subunit;DPM synthase complex, catalytic subunit;DPM synthase subunit 1;mannose-P-dolichol synthase subunit 1;MPD synthase subunit 1;MPDS
- Extra Details:
- Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice