E-AB-62764
GLUD1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-62764
- Additional Names:
- GDH,GDH1,GLUD,GLUD1
- Application:
- IHC, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human GLUD1 (NP_005262.1).
- Uniprot:
- P00367
- Synonyms:
- epididymis secretory sperm binding protein;epididymis tissue sperm binding protein Li 18mP;GDH;GDH1;GLUD;glutamate dehydrogenase (NAD(P)+);glutamate dehydrogenase 1, mitochondrial
- Extra Details:
- This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
- Shipping Conditions:
- Blue Ice