E-AB-62677
CIDEA Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-62677
- Additional Names:
- CIDE-A,CIDEA
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human CIDEA (NP_001270.1).
- Uniprot:
- O60543
- Synonyms:
- cell death activator CIDE-A;Cell death-inducing DFFA-like effector A;CIDE-A
- Extra Details:
- This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.
- Shipping Conditions:
- Blue Ice