E-AB-62492
BCCIP Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-62492
- Additional Names:
- BCCIP,TOK-1,TOK1
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human BCCIP (NP_510868.1).
- Uniprot:
- Q9P287
- Synonyms:
- BCCIPalpha;BCCIPbeta;BRCA2 and CDKN1A-interacting protein;BRCA2 and Cip1/p21 interacting protein;cdk inhibitor p21 binding protein;p21- and CDK-associated protein 1;protein TOK-1;TOK-1;TOK-1alpha;TOK-1beta;TOK1
- Extra Details:
- This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
- Shipping Conditions:
- Blue Ice