E-AB-62489
DMAP1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-62489
- Additional Names:
- DMAP1,DNMAP1,DNMTAP1,EAF2,MEAF2,SWC4
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human DMAP1 (NP_061973.1).
- Uniprot:
- Q9NPF5
- Synonyms:
- DNA methyltransferase 1-associated protein 1;DNMAP1;DNMT1 associated protein 1;DNMTAP1;EAF2;MEAF2;SWC4
- Extra Details:
- This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
- Shipping Conditions:
- Blue Ice