E-AB-62250
(KO Validated) HIRA Polyclonal Antibody
Size
£210.60
Was £234.00
- SKU:
- E-AB-62250
- Additional Names:
- DGCR1,HIRA,TUP1,TUPLE1
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human HIRA (NP_003316.3).
- Uniprot:
- P54198
- Synonyms:
- DGCR1;DiGeorge critical region gene 1;HIR histone cell cycle regulation defective homolog A;histone regulator A;protein HIRA;TUP1;TUP1-like enhancer of split protein 1;TUPLE1
- Extra Details:
- This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
- Shipping Conditions:
- Blue Ice