E-AB-62211
SFPQ Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-62211
- Additional Names:
- POMP100,PPP1R140,PSF,SFPQ
- Application:
- IHC, WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human SFPQ (NP_005057.1).
- Uniprot:
- P23246
- Synonyms:
- 100 kDa DNA-pairing protein;DNA-binding p52/p100 complex, 100 kDa subunit;epididymis secretory sperm binding protein;polypyrimidine tract binding protein associated;polypyrimidine tract-binding protein-associated splicing factor;Polypyrimidine tract-binding protein-associated-splicing factor;POMP100;PPP1R140;protein phosphatase 1, regulatory subunit 140;PSF;PTB-associated splicing factor;splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated);splicing factor proline/glutamine-rich;splicing factor, proline- and glutamine-rich
- Extra Details:
- DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells, T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A.
- Shipping Conditions:
- Blue Ice