E-AB-61945
SSRP1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-61945
- Additional Names:
- FACT,FACT80,SSRP1,T160
- Application:
- IHC, WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human SSRP1 (NP_003137.1).
- Uniprot:
- Q08945
- Synonyms:
- chromatin-specific transcription elongation factor 80 kDa subunit;cisplatin-DNA SSRP;facilitates chromatin remodeling 80 kDa subunit;facilitates chromatin transcription complex 80 kDa subunit;facilitates chromatin transcription complex subunit SSRP1;FACT;FACT 80 kDa subunit;FACT complex subunit SSRP1;FACT80;FACTp80;high mobility group box;hSSRP1;recombination signal sequence recognition protein 1;Structure-specific recognition protein 1;T160
- Extra Details:
- The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
- Shipping Conditions:
- Blue Ice