PCBD1 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-61927
Additional Names:: DCOH,PCBD,PCBD1,PCD,PHS
Application:: IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human PCBD1 (NP_000272.1).
Uniprot:: P61457
Synonyms:: 4-alpha-hydroxy-tetrahydropterin dehydratase;6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1);DCOH;Dimerization cofactor of hepatocyte nuclear factor 1-alpha;dimerizing cofactor for HNF1;PCBD;PCD;phenylalanine hydroxylase-stimulating protein;PHS;Pterin carbinolamine dehydratase;pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha;pterin-4-alpha-carbinolamine dehydratase
Extra Details:: This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants.