E-AB-61892
PHF21A Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-61892
- Additional Names:
- BHC80,BM-006,PHF21A
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human PHF21A (NP_001095272.1).
- Uniprot:
- Q96BD5
- Synonyms:
- BHC80;BHC80a;BM-006;BRAF35-HDAC complex protein BHC80;BRAF35/HDAC2 complex (80 kDa);IDDBCS;NEDMS;PHD finger protein 21A
- Extra Details:
- Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events.
- Shipping Conditions:
- Blue Ice