E-AB-61633
RNF7 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-61633
- Additional Names:
- CKBBP1,RNF7,ROC2,SAG
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human RNF7 (NP_055060.1).
- Uniprot:
- Q9UBF6
- Synonyms:
- CKBBP1;CKII beta-binding protein 1;rbx2;regulator of cullins 2;RING finger protein 7;RING-box protein 2;ROC2;SAG;sensitive to apoptosis gene protein;sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2;zinc RING finger protein SAG
- Extra Details:
- The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
- Shipping Conditions:
- Blue Ice