IKZF3 Polyclonal Antibody

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£195.30

Was £217.00

SKU:: E-AB-61621
Additional Names:: AIO,AIOLOS,IKZF3,ZNFN1A3
Application:: IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human IKZF3 (NP_036613.2).
Uniprot:: Q9UKT9
Synonyms:: AIO;AIOLOS;Ikaros family zinc finger protein 3;IMD84;zinc finger DNA binding protein Aiolos;zinc finger protein Aiolos;zinc finger protein, subfamily 1A, 3 (Aiolos);ZNFN1A3
Extra Details:: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.