E-AB-61616
DUSP22 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-61616
- Additional Names:
- DUSP22,JKAP,JSP-1,JSP1,LMW-DSP2,LMWDSP2,MKP-x,MKPX,VHX
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human DUSP22 (NP_064570.1).
- Uniprot:
- Q9NRW4
- Synonyms:
- dual specificity protein phosphatase 22;epididymis secretory sperm binding protein;homolog of mouse dual specificity phosphatase LMW-DSP2;JKAP;JNK-stimulating phosphatase 1;JNK-stimulatory phosphatase-1;JSP-1;JSP1;LMW-DSP2;LMWDSP2;low molecular weight dual specificity phosphatase 2;MAP kinase phosphatase x;mitogen-activated protein kinase phosphatase x;MKP-x;MKPX;VHX
- Extra Details:
- Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.
- Shipping Conditions:
- Blue Ice