NCOR1 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-61490
Additional Names:: N-CoR,N-CoR1,NCOR1,PPP1R109,TRAC1,hN-CoR
Application:: IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human NCOR1 (NP_006302.2).
Uniprot:: O75376
Synonyms:: hN-CoR;N-CoR;N-CoR1;nuclear receptor corepressor 1;PPP1R109;protein phosphatase 1, regulatory subunit 109;thyroid hormone- and retinoic acid receptor-associated corepressor 1;TRAC1
Extra Details:: This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.