E-AB-61474
EIF3C Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-61474
- Additional Names:
- EIF3C,EIF3CL,EIF3S8,eIF3-p110
- Application:
- IHC, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human EIF3C (NP_003743.1).
- Uniprot:
- Q99613
- Synonyms:
- cell migration-inducing protein 17;eIF3 p110;eIF3-p110;EIF3CL;EIF3S8;eukaryotic translation initiation factor 3 subunit 8;eukaryotic translation initiation factor 3 subunit C;eukaryotic translation initiation factor 3, subunit 8 (110kD);eukaryotic translation initiation factor 3, subunit 8, 110kDa
- Extra Details:
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
- Shipping Conditions:
- Blue Ice