E-AB-61419
PDE6B Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-61419
- Additional Names:
- CSNB3,CSNBAD2,GMP-PDEbeta,PDE6B,PDEB,RP40,rd1
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human PDE6B (NP_001138763.1).
- Uniprot:
- P35913
- Synonyms:
- CSNB3;CSNBAD2;GMP-PDE beta;GMP-PDEbeta;PDEB;phosphodiesterase 6B, cGMP-specific, rod, beta;rd1;rod cGMP-phosphodiesterase beta-subunit;rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta;RP40
- Extra Details:
- Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice