E-AB-61418
PARN Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-61418
- Additional Names:
- DAN,DKCB6,PARN,PFBMFT4
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human PARN (NP_002573.1).
- Uniprot:
- O95453
- Synonyms:
- DAN;deadenylating nuclease;deadenylation nuclease;DKCB6;PFBMFT4;poly(A)-specific ribonuclease PARN;polyadenylate-specific ribonuclease
- Extra Details:
- The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice