E-AB-61412
AFF1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-61412
- Additional Names:
- AF4,AFF1,MLLT2,PBM1
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human AFF1 (NP_001160165.1).
- Uniprot:
- P51825
- Synonyms:
- AF4;AF4/FMR2 family member 1;ALL1-fused gene from chromosome 4 protein;MLLT2;myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2;PBM1;pre-B-cell monocytic leukemia partner 1;Protein FEL;proto-oncogene AF4
- Extra Details:
- This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice