E-AB-60939
ACTL6A Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-60939
- Additional Names:
- ACTL6,ACTL6A,ARPN-BETA,Arp4,BAF53A,INO80K
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human ACTL6A (NP_004292.1).
- Uniprot:
- O96019
- Synonyms:
- 53 kDa BRG1-associated factor A;actin-like protein 6A;actin-related protein 4;actin-related protein Baf53a;ACTL6;Arp4;ARPN-BETA;arpNbeta;BAF complex 53 kDa subunit;BAF53;BAF53A;BRG1-associated factor 53A;hArpN beta;INO80 complex subunit K;INO80K;SMARCN1
- Extra Details:
- This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila, the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
- Shipping Conditions:
- Blue Ice