SETD2 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-60870
Additional Names:: HBP231,HIF-1,HIP-1,HSPC069,HYPB,KMT3A,LLS,SET2,SETD2,p231HBP
Application:: IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human SETD2 (NP_054878.5).
Uniprot:: Q9BYW2
Synonyms:: HBP231;HIF-1;HIP-1;histone-lysine N-methyltransferase SETD2;HSPC069;huntingtin interacting protein 1;huntingtin yeast partner B;Huntingtin-interacting protein 1;huntingtin-interacting protein B;HYPB;KMT3A;LLS;lysine N-methyltransferase 3A;p231HBP;protein-lysine N-methyltransferase SETD2;SET domain-containing protein 2;SET2
Extra Details:: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.