E-AB-60796
EIF4G2 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-60796
- Additional Names:
- AAG1,DAP5,EIF4G2,NAT1,P97
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human EIF4G2 (NP_001409.3).
- Uniprot:
- P78344
- Synonyms:
- AAG1;aging-associated protein 1;DAP-5;DAP5;death-associated protein 5;eIF-4-gamma 2;eIF-4G 2;eIF4G 2;eukaryotic translation initiation factor 4 gamma 2;eukaryotic translation initiation factor 4G-like 1;NAT1;P97
- Extra Details:
- Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3, eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
- Shipping Conditions:
- Blue Ice