TAP2 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-60369
Additional Names:: ABC18,ABCB3,APT2,D6S217E,PSF-2,PSF2,RING11,TAP2
Application:: IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human TAP2 (NP_000535.3).
Uniprot:: Q03519
Synonyms:: ABC transporter, MHC 2;ABC18;ABCB3;antigen peptide transporter 2;APT2;ATP-binding cassette sub-family B member 3;ATP-binding cassette, sub-family B (MDR/TAP), member 3;D6S217E;peptide supply factor 2;peptide transporter involved in antigen processing 2;peptide transporter PSF2;Peptide transporter TAP2;PSF-2;PSF2;really interesting new gene 11 protein;RING11;transporter 2, ABC (ATP binding cassette);transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Extra Details:: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.

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