E-AB-60301
MICA Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-60301
- Additional Names:
- MIC-A,MICA,PERB11.1
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human MICA (NP_000238.1).
- Uniprot:
- Q29983
- Synonyms:
- HLA class I antigen;major histocompatibility complex class I chain-related protein A;MHC class I chain-related protein A;MHC class I polypeptide-related sequence A;MHC class I related chain A;MHC class I related sequence A;MIC-A;PERB11.1;stress inducible class I homolog;truncated MHC class I polypeptide-related sequence A;truncated MICA
- Extra Details:
- This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice