E-AB-60194
TTR Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-60194
- Additional Names:
- CTS,CTS1,HEL111,HsT2651,PALB,TBPA,TTR
- Application:
- IHC, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human TTR (NP_000362.1).
- Uniprot:
- P02766
- Synonyms:
- ATTR;CTS;CTS1;epididymis luminal protein 111;HEL111;HsT2651;PALB;Prealbumin;prealbumin, amyloidosis type I;TBPA;thyroxine-binding prealbumin;transthyretin;TTN
- Extra Details:
- This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein, it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported, most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
- Shipping Conditions:
- Blue Ice