E-AB-60140
TPMT Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-60140
- Additional Names:
- TPMT,TPMTD
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human TPMT (NP_000358.1).
- Uniprot:
- P51580
- Synonyms:
- S-adenosyl-L-methionine:thiopurine S-methyltransferase;Thiopurine methyltransferase;thiopurine S-methyltransferase;TPMTD
- Extra Details:
- This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
- Shipping Conditions:
- Blue Ice