E-AB-53528
NF1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-53528
- Additional Names:
- DKFZp686J1293,FLJ21220,NF,Neurofibromatosis Noonan syndrome,Neurofibromatosis related protein NF 1,Neurofibromatosis related protein NF1,Neurofibromatosis-related protein NF-1,Neurofibromin 1,Neurofibromin truncated,Neurofibromin1,neurofibromatosis type I
- Application:
- IHC
- Concentration:
- 1.7 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human NF1
- Uniprot:
- P21359
- Synonyms:
- neurofibromatosis 1;neurofibromatosis-related protein NF-1;neurofibromin;NFNS;truncated neurofibromin 1;VRNF;WSS
- Extra Details:
- This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.NF1 (Neurofibromin 1) is a Protein Coding gene. Diseases associated with NF1 include Neurofibromatosis-Noonan Syndrome and Neurofibromatosis, Type 1. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and RET signaling. GO annotations related to this gene include binding and phosphatidylcholine binding.
- Shipping Conditions:
- Blue Ice