E-AB-53395
GRM2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-53395
- Additional Names:
- AMPA selective glutamate receptor 2 ,GLUR2,GLURB,GPRC1B,GRM2,Glutamate metabotropic receptor 2,Glutamate receptor homolog,Glutamate receptor metabotropic 2,Metabotropic glutamate receptor 2,OTTHUMP00000210984,OTTHUMP00000210986,mGlu2,mGluR2
- Application:
- IHC
- Concentration:
- 0.96 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human GRM2
- Uniprot:
- Q14416
- Synonyms:
- GLUR2;glutamate receptor homolog;glutamate receptor, metabotropic 2;GPRC1B;metabotropic glutamate receptor 2;mGlu2;MGLUR2
- Extra Details:
- L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice