E-AB-53135
HORMAD2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-53135
- Additional Names:
- 4930529M09Rik,CT46.2,HORM2,HORMA domain containing 2,HORMA domain-containing protein 2,Hormad2,MGC26710,RP23-329P17.4
- Application:
- IHC
- Concentration:
- 0.96 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human HORMAD2
- Uniprot:
- Q8N7B1
- Synonyms:
- CT46.2;HORMA domain-containing protein 2
- Extra Details:
- Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).
- Shipping Conditions:
- Blue Ice