E-AB-52943
RIC8A Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52943
- Additional Names:
- MGC104517,MGC131931,MGC148073,MGC148074,Protein Ric-8A,RIC8,RIC8A,Synembryn-A,resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
- Application:
- IHC
- Concentration:
- 1.44 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human RIC8A
- Uniprot:
- Q9NPQ8
- Synonyms:
- Protein Ric-8A;resistance to inhibitors of cholinesterase 8 homolog A;RIC8;synembryn-A
- Extra Details:
- Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
- Shipping Conditions:
- Blue Ice