E-AB-52933
SETDB1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52933
- Additional Names:
- AU022152,EC 2.1.1.43,ERG-associated protein with SET domain,ESET,H3 K9 HMTase 4,H3-K9-HMTase 4,H3-K9-HMTase4,Histone H3 K9 methyltransferase 4,Histone H3-K9 methyltransferase 4,Histone-lysine N-methyltransferase SETDB1,KG1T,KIAA0067,KMT1E,Lysine N-methylt
- Application:
- IHC
- Concentration:
- 1.08 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human SETDB1
- Uniprot:
- Q15047
- Synonyms:
- ERG-associated protein with a SET domain, ESET;ERG-associated protein with SET domain;ESET;H3-K9-HMTase4;histone H3-K9 methyltransferase 4;histone-lysine N-methyltransferase SETDB1;histone-lysine N-methyltransferase, H3lysine-9 specific 4;KG1T;KMT1E;lysine N-methyltransferase 1E;SET domain bifurcated 1;TDRD21;tudor domain containing 21
- Extra Details:
- SETDB1,also named as ESET,KIAA0067 and KMT1E,belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions,thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation,gene silencing,and transcriptional repression. It has been identified as a target for treatment in Huntington Disease,given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.
- Shipping Conditions:
- Blue Ice