E-AB-52908
EWSR1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52908
- Additional Names:
- EWS,EWS RNA binding protein 1,EWS oncogene,EWSR 1,EWSR1 protein,Ewing sarcoma breakpoint region 1,Ewing sarcoma breakpoint region 1 protein,Ewings sarcoma EWS Fli1 type 1 oncogene,Ewsr1,RNA,bK984G1.4,bK984G1.4 Ewing sarcoma breakpoint region 1 protein
- Application:
- IHC, WB
- Concentration:
- 1.08 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human EWSR1
- Uniprot:
- Q01844
- Synonyms:
- bK984G1.4;Ewing sarcoma breakpoint region 1;Ewing sarcoma breakpoint region 1 protein;Ewings sarcoma EWS-Fli1 (type 1) oncogene;EWS;EWS oncogene;EWS RNA-binding protein variant 6;EWS-FLI1;RNA-binding protein EWS
- Extra Details:
- This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11,22)(q24,q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
- Shipping Conditions:
- Blue Ice