E-AB-52592
IMPA1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52592
- Additional Names:
- IMP,IMP 1,IMPA,IMPA 1,IMPA1,IMPase,IMPase 1,Inositol 1(or 4) monophosphatase,Inositol monophosphatase,Inositol monophosphatase 1,Inositol(myo) 1(or 4) monophosphatase 1,Inositol-1(or 4)-monophosphatase 1,Lithium sensitive myo inositol monophosphatas
- Application:
- WB
- Concentration:
- 0.72 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human IMPA1
- Uniprot:
- P29218
- Synonyms:
- D-galactose 1-phosphate phosphatase;IMP;IMP 1;IMPA;IMPase 1;inositol monophosphatase 1;inositol-1(or 4)-monophosphatase 1;inositol(myo)-1(or 4)-monophosphatase 1;lithium-sensitive myo-inositol monophosphatase A1;MRT59;myo-inositol monophosphatase 1;testicular tissue protein Li 94
- Extra Details:
- This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
- Shipping Conditions:
- Blue Ice