E-AB-52510
IL6ST Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52510
- Additional Names:
- CDW,IL6ST,CD130,CDW130,GP130,IL-6RB,Interleukin 6 signal transducer,IR6RB,CD130 antigen,GP130 RAPS,IL 6R beta,IL-6 receptor subunit beta,IL6 ST,IL-6R subunit beta,IL6RB,IL-6R-beta,Interleukin 6 receptor subunit beta,Interleukin receptor beta chain,Interleukin-6 receptor subunit beta,Interleukin-6 signal transducer,Membrane glycoprotein 130,Membrane glycoprotein gp130,Oncostatin M receptor,Oncostatin M receptor alpha subunit,Oncostatin-M receptor subunit alpha
- Application:
- IHC
- Concentration:
- 0.7 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human IL6ST
- Uniprot:
- P40189
- Synonyms:
- CD130;CD130 antigen;CDW130;GP130;gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form;gp130, oncostatin M receptor;HIES4;IL-6 receptor subunit beta;IL-6R subunit beta;IL-6RB;interleukin receptor beta chain;interleukin-6 receptor subunit beta;interleukin-6 signal transducer;membrane glycoprotein 130;membrane glycoprotein gp130;oncostatin-M receptor subunit alpha;sGP130
- Extra Details:
- The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
- Shipping Conditions:
- Blue Ice