E-AB-52359
GCLC Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52359
- Additional Names:
- EC 6.3.2.2,GCL,GCS,GCS heavy chain,GLCL,GLCLC,GSH1,Gamma ECS,Gamma glutamylcysteine synthetase,Gamma-ECS,Gamma-glutamylcysteine synthetase,Gclc,Glutamate cysteine ligase catalytic subunit,Glutamate--cysteine ligase catalytic subunit
- Application:
- IHC, WB
- Concentration:
- 0.8 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human GCLC
- Uniprot:
- P48506
- Synonyms:
- gamma-ECS;gamma-glutamylcysteine synthetase;GCL;GCS;GCS heavy chain;GLCL;GLCLC;glutamate--cysteine ligase catalytic subunit
- Extra Details:
- Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
- Shipping Conditions:
- Blue Ice