E-AB-52350
ALKBH8 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52350
- Additional Names:
- 4930562C03Rik,8030431D03Rik,9430088N01Rik,ABH8,ALKB8,ALKBH8,AlkB homologue 8,Alkylated DNA repair protein alkB homolog 8,FLJ38204,MGC10235,OTTHUMP00000211286,OTTHUMP00000211287,Pr,alkB alkylation repair homolog 8,alkB alkylation repair homolog 8 (E. coli)
- Application:
- IHC, WB
- Concentration:
- 0.6 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Full length fusion protein
- Uniprot:
- Q96BT7
- Synonyms:
- ABH8;AlkB homologue 8;alkB, alkylation repair homolog 8;alkylated DNA repair protein alkB homolog 8;MRT71;probable alpha-ketoglutarate-dependent dioxygenase ABH8;S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8;TRM9;TRMT9;TRMT9A;tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8;tRNA methyltransferase 9 homolog;tRNA methyltransferase 9 related
- Extra Details:
- ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene.
- Shipping Conditions:
- Blue Ice