PTPRN Polyclonal Antibody

Size

£106.20

Was £118.00

SKU:: E-AB-52202
Additional Names:: CA 512,FLJ16131,IA 2,IA 2/PTP,IA2,IA2/PTP,ICA 3,ICA 512,ICA3,ICA512,Islet cell antigen 2,Islet cell antigen 512,Islet cell autoantigen 3,Protein tyrosine phosphatase like N,Protein tyrosine phosphatase like N precursor,Protein tyrosine phosphatase recepto
Application:: IHC
Concentration:: 0.96 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Fusion protein of human PTPRN
Uniprot:: Q16849
Synonyms:: IA-2;IA-2/PTP;IA2;ICA 512;ICA512;insulinoma-associated tyrosine-phosphatase-like protein;islet cell antigen 2;islet cell antigen 512;islet cell autoantigen 3;protein tyrosine phosphatase-like N;PTP IA-2;R-PTP-N;receptor-type tyrosine-protein phosphatase-like N
Extra Details:: IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family,which contains a transmembrane region,an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker.