E-AB-52192
HSD11B1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52192
- Additional Names:
- 11 DH,11 beta HSD 1,11 beta HSD1,11 beta hydroxysteroid dehydrogenase 1,11-DH,11-beta hydroxysteroid dehydrogenase,11-beta-HSD1,11-beta-hydroxysteroid dehydrogenase 1,11DH,Corticosteroid 11 beta dehydrogenase isozyme 1,Corticosteroid 11-beta-dehydr,type 1
- Application:
- IHC
- Concentration:
- 1.2 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human HSD11B1
- Uniprot:
- P28845
- Synonyms:
- 11-beta-HSD1;11-beta-hydroxysteroid dehydrogenase 1;11-DH;corticosteroid 11-beta-dehydrogenase isozyme 1;CORTRD2;HDL;HSD11;HSD11B;HSD11L;SDR26C1;short chain dehydrogenase/reductase family 26C member 1
- Extra Details:
- The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
- Shipping Conditions:
- Blue Ice