E-AB-52172
PPM1D Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52172
- Additional Names:
- EC 3.1.3.16,PP2C delta,PP2C-delta,PP2CD,PPM1D,Ppm1d,Protein phosphata,Protein phosphatase 1D,Protein phosphatase 2C delta isoform,p53 induced protein phosphatase 1,p53-induced protein phosphatase 1,protein phosphatase 1D magnesium-dependent delta isoform
- Application:
- IHC
- Concentration:
- 0.5 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human PPM1D
- Uniprot:
- O15297
- Synonyms:
- IDDGIP;JDVS;p53-induced protein phosphatase 1;PP2C-DELTA;protein phosphatase 1D;Protein phosphatase 2C isoform delta;Protein phosphatase magnesium-dependent 1 delta;protein phosphatase Wip1;wild-type p53-induced phosphatase 1;WIP1
- Extra Details:
- The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
- Shipping Conditions:
- Blue Ice