E-AB-52102
CEMIP Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52102
- Additional Names:
- IR2155535,KIAA1199 protein,OTTHUMP00000185569 ,OTTHUMP00000195036,TMEM2L,Transmembrane protein 2 like
- Application:
- IHC
- Concentration:
- 0.78 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human CEMIP
- Uniprot:
- Q8WUJ3
- Synonyms:
- CCSP1;cell migration inducing hyaluronan binding protein;cell migration inducing protein, hyaluronan binding;cell migration-inducing and hyaluronan-binding protein;colon cancer secreted protein 1;hyaluronan-binding protein involved in hyaluronan depolymerization;HYBID;KIAA1199;TMEM2L
- Extra Details:
- Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
- Shipping Conditions:
- Blue Ice