E-AB-52020
IL4R Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-52020
- Additional Names:
- 582J,IL4R,CD124,IL-4RA,IL4RA,IL-4 receptor subunit alpha,IL-4-binding protein,IL4-BP,IL-4R subunit alpha,IL-4R-alpha,Interleukin-4 receptor subunit alpha,582J2.1,IL-4R&,alpha,IL 4R alpha,IL4R nirs variant 1,IL4RA,Interleukin 4 receptor,Interleukin 4 receptor alpha chain,sIL4Ralpha/prot,Soluble IL-4 receptor subunit alpha,Soluble IL-4R-alpha,Soluble interleukin-4 receptor subunit alpha
- Application:
- IHC
- Concentration:
- 1.26 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human IL4R
- Uniprot:
- P24394
- Synonyms:
- CD124;IL-4 receptor subunit alpha;IL-4RA;IL4R nirs variant 1;IL4RA;interleukin 13 receptor;interleukin-4 receptor alpha chain;interleukin-4 receptor subunit alpha
- Extra Details:
- This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice