E-AB-51043
Phospho-SMAD3 (Ser425) Monoclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-51043
- Additional Names:
- DKFZP586N0721,DKFZp686J10186,HSPC193,HST17436,JV15 2,JV15-2,JV152,LDS1C,LDS3,MAD,MAD (mothers against decapentaplegic Drosophila) homolog 3,MAD homolog 3,Mad homolog JV15 2,Mad protein homolog,hMAD 3,hMAD-3,hSMAD3,mothers against decapentaplegic homolog 3
- Application:
- IHC, IHC-P
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Mouse
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthetic Peptide of Phospho-Smad3 (Ser425)
- Clone:
- 4C5
- Uniprot:
- P84022
- Synonyms:
- hMAD-3;hSMAD3;HSPC193;HsT17436;JV15-2;LDS1C;LDS3;MAD homolog 3;mad homolog JV15-2;mad protein homolog;MAD, mothers against decapentaplegic homolog 3;mad3;MADH3;mothers against decapentaplegic homolog 3;mothers against DPP homolog 3;SMA- and MAD-related protein 3;SMAD family member 3;SMAD, mothers against DPP homolog 3
- Extra Details:
- Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
- Shipping Conditions:
- Blue Ice