E-AB-48028
DNA-RNA Hybrid Monoclonal Antibody[S9.6]
Size
£120.60
Was £134.00
- SKU:
- E-AB-48028
- Additional Names:
- DNA-RNA hybrid,RNA/DNA hybrid
- Application:
- ChIP, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A/G Purification
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Mouse
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- F PhiX174 bacteriophage-derived synthetic DNA/RNA
- Clone:
- S9.6
- Extra Details:
- The DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. The S9.6 monoclonal antibody recognizes DNA-RNA hybrids (also known as R-loops) and does not bind to single or double stranded DNA. The antibody has high affinity for DNA-RNA hybrids but also binds RNA-RNA hybrids that are AU-rich. The specificity of the antibody appears to be determined by a combination of sequence and structural dependency since R-loop sequence affects binding affinity.
- Shipping Conditions:
- Blue Ice